He started his service career in the Agricultural Development Finance Corporation, Dhaka with head office in Karachi as Investigation Officer in 1958. Then he sat for the competitive Examination conducted by the Public Service Commission. Being successful he was appointed by the Government in the then East Pakistan Secretariat Service and joined as Section Officer in 1960. In the same year he also sat for the then East Pakistan Civil Service Examination conducted by the Public Service Commission and being successful he was appointed by the Government in the then East Pakistan Civil Service as Extra Assistant Commissioner in the year 1961. He served as Deputy Magistrate and Deputy Collector in different Sub-Divisions and Districts from 1961-1964. He worked as Project Director, Comilla District Integrated Rural Development Programme from 1964-68. He was one of the Pioneers of the Comilla Model Rural Development through two tier Co-operative Movement introduced by Akhter Hamid Khan then Director of the Pakistan Academy for Rural Development (PARD), Comilla now known as BARD.

Mr. Hossain Khan worked as Resident Magistrate, Sherpur having Jurisdiction over four (04) thanas. He also worked as Chairman, Sherpur Municipality and Chairman, Sherpur Thana Council. He had the unique opportunity of being the Centennial Chairman of the Sherpur Municipality. During his time the Municipality observed hundred years of its establishment and providing Municipal Service to the people of the locality.

He had the opportunity of working in the then Pakistan Secretariat, Islamabad, Capital of Pakistan.

He was Sub-Divisional Officer (SDO) of Jhenaidah Sub-Division during the period from 1974-75 and Addl. Deputy Commissioner (General), Chittagong from 1975-77. He also worked as Member, Offshore Islands Development Board and Head of Estate Department (CEO) of Bangladesh Railways.

Mr. Hossain served as Deputy Secretary, Ministry of Fisheries and Livestock for the period from 1982-84. He was the first Civil Servant to be appointed in the Department of Fisheries as Addl. Director of Fisheries and later Project Director, Shrimp Culture Development Project. The department is considered as the domain of the Fishery Experts/Professionals. So his appointment in the Department was unique in nature.

He worked as Joint Secretary, Ministry of Environment and Forest during the year 1988-91. After the devastating Cyclone of April, 1991 he moved to the Ministry of Relief later renamed as Ministry of Disaster Management and Relief which is the focal point for disaster related activities in Bangladesh. As Joint Secretary he was actively engaged in reaching and providing all assistance to the Victims of 1991 April Cyclone that devasted 19 districts of Bangladesh. He successfully tackled the situation created out of successive floods of 1991 and 1993.

He also worked as Director General, Disaster Management Bureau (DMB) and Director General, Deptt. of Relief and Rehabilitation.

During his service period he attended and received Training from the following institutions -
* As a British Council Scholar he attended Birmingham University (UK) for one year and obtained
   Post Graduate Diploma in Development Administration during the year 1978-79.
* Gazetted Officers' Training Academy, Dhaka for 06 months.
* Local Govt. Institute, Dhaka.
* Census, Survey and Settlement Training Course.
* Pakistan Academy for Rural Development, Comilla in Rural Development, Co-operative,
   Management, Administration and Development (09 months).
* International Seminar-Cum-Training on Disaster Management & Planning in Moscow, USSR.
* Asian Disaster Preparedness Centre, Bangkok

He qualified as CMIBP from the Institute of Bankers in Pakistan, Karachi and stood first on all Pakistan basis with distinction in Book-Keeping. He also successfully completed Part-1 of DAIBP from the same Institute.

Business Venture -
On his retirement from Govt. Service in 1993 Mr. A.Z.M Hossain Khan started business with other friends and relatives forming Private Limited Company of which he was the Managing Director. He was also Managing Director of German Bangla Joint Venture Food Ltd. He is the Managing Director of Technopro Ltd.